Overview

SLAP


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1. Src-like adaptor proteins. Dimeric adaptor proteins, SLA (281 aa) and SLA2 (261 aa), that are negative regulators of T-cell and B-cell immune responses. Through their SH3 and SH2 domains they interact with the T- or B-cell receptor complexes and with the ubiquitin ligase, cbl.

2. Sarcolemmal-associated protein, an integral membrane protein (828 aa with smaller isoforms) that may interact with myosin and is found in transverse tubules, near the junctional sarcoplasmic reticulum and along the Z- and M-lines in cardiomyocytes. NB The term ‘sarcolemmal associated protein’ is also used loosely of dystrophin

Subjects: Medicine and Health.


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