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Sex-determining region Y, the gene at p11.3 on the Y chromosome that is both required and sufficient to initiate testis development in human embryos. SRY is an intronless gene that spans 3.8 kb. It encodes a 204 amino acid protein which regulates the transcription of the genes that function in sexual differentiation by binding to target sequences in their DNAs. XY individuals with loss-of-function mutations in the SRY gene are phenotypically female, but with rudimentary ovaries. See Chronology, 1987, Page et al.; 2003, Skaletsky et al.; human Y chromosome, selector genes, sex determination, Y chromosome.

Subjects: Genetics and Genomics.

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