A nonprogressive retinal disorder characterized by impaired night vision because of reduced or absent retinal rods. An X-linked form (type 1) is caused by mutation in nyctalopin; the type 2 X-linked form by mutation in the retina-specific calcium channel α1-subunit. Autosomal recessive forms can be caused by mutation in the metabotropic glutamate receptor-6 or in calcium-binding protein-4. Autosomal dominant forms can be caused by mutations in rhodopsin, cyclic nucleotide phosphodiesterase-6B or in rod-specific transducin. The Oguchi-type stationary night blindness, in which dark adaptation is abnormally slow, is caused by mutation in arrestin or in rhodopsin kinase.
Subjects: Medicine and Health.