sticky ends

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Complementary single-stranded projections from opposite ends of a DNA duplex or from different duplex molecules that are terminally redundant. Sticky ends allow the splicing of hybrid molecules in recombinant DNA experiments. Many restriction endonucleases (q.v.) create sticky ends by making staggered cuts (q.v.) in a palindromic restriction site. Also called cohesive ends. See Chronology, 1970, Smith and Wilcox.

Subjects: Genetics and Genomics — Medicine and Health.

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