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The major negative regulator of the sonic hedgehog/*patched signalling pathway in vertebrates (suppressor of fused). The human gene has 40% homology with the Drosophila gene and the product (484 aa) inhibits the transcriptional activity of gli-1 (glioma-associated oncogene-1) and osteogenic differentiation in response to sonic hedgehog signalling.

Subjects: Medicine and Health.

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