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sulphonylurea receptor


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(SUR)

An ABC transporter family member (ABCC8, SUR1, 1581 aa) that regulates glucose-induced insulin secretion by an effect on inwardly rectifying potassium–ATP channels (Kir6.2) in pancreatic beta cells. Four Kir6.2 subunits form the pore and interact with four regulatory subunits (SUR1) each with two nucleotide-binding folds (NBFs) that sense changes in the ATP:ADP ratio in the cell. Tritiated glibenclamide is often used to detect their tissue distribution.

Subjects: Medicine and Health.


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