An extensive family of integral membrane proteins that are the receptors (SNAREs) for intracellular transport vesicles. They bind synaptotagmin in a calcium-dependent fashion and interact with voltage-dependent calcium and potassium channels. Syntaxin 1 (288 aa) functions specifically in neurotransmitter release in the brain, whereas syntaxins 2, 3, and 4 have a wider tissue distribution. Syntaxin-1a and -4 preferentially interact with β- and β-*taxilin respectively. Syntaxin 5 is a Golgi-localized SNARE protein that has been shown to be required for endoplasmic reticulum–Golgi traffic. Syntaxins are the target for botulinum neurotoxin type C.
Subjects: Medicine and Health.