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synuclein


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A family of structurally related proteins (α, β, and γ-synuclein) that are abundant in neurons and form aggregates in various neurodegenerative diseases. α-Synuclein (140 aa) is a component of plaque amyloid in Alzheimer's disease and accumulates in Lewy bodies, and an α-synuclein allele is linked to various familial cases of Parkinson's disease, interacts with synphilin, and is degraded by neurosin.

Subjects: Medicine and Health — Chemistry.


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