A family of proteins (transforming, acidic, coiled-coil-containing proteins) that are rich in serine, proline, and acidic residues, have nuclear localization signals but no DNA- or RNA-binding domains. Expression of TACC1 (805 aa) in stable cell lines induces a transformed phenotype and anchorage-independent growth. TACC1 interacts with products of CHTOG (colonic and hepatic tumour overexpressed gene, cytoskeleton-associated protein 5, CKAP5) and GAS41 (glioma-amplified sequence 41). TACC2 (652 aa) is very similar to TACC1; TACC3 (838 aa) lacks nuclear localization signals and is strongly expressed in most tumour cell lines tested. Phosphorylation of TACC3 by aurora A is essential for proper localization of TACC3 to centrosomes and proximal mitotic spindles.
Subjects: Medicine and Health.