Overview

TACE


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A zinc metallopeptidase (TNFα converting enzyme, ADAM17, EC 3.4.24.-, 827 aa) of the ADAM family that releases soluble TNFα from the inactive membrane-bound precursor. It is also involved in cleavage and release of fractalkine (CX3CL1) and in notch signalling.

Subjects: Medicine and Health.


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