In the earlier literature this marine pufferfish is called Fugu rubripes. Pufferfish have the most compact genomes seen in vertebrates. The value (400 Mb) is 7.5 times smaller than the human genome. The number of ORFs is similar in both species, but the pufferfish has genes with smaller introns, the intergenic sequences are smaller, and there is less repetitive DNA. The compaction of the genome appears to result from the selection of deletions during the evolution of the fish. Duplicate genes are common in the pufferfish genome, and a phylogenetic analysis suggests the ancestral genome was duplicated early during the evolution of the Osteichthyes. See Classification, Chordata, Osteichthyes, Neopterygii, Tetraodontiformes; Chronology, 2002, Aparicio et al.;, Species Web Sites; Huntington disease (HD), Linnean system of binomial nomenclature, shotgun sequencing, Tetraodon nigroviridis.
Subjects: Genetics and Genomics.