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TDP-43


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'TDP-43' can also refer to...

TDP-43

Characterizing TDP-43 interaction with its RNA targets

PABPN1 suppresses TDP-43 toxicity in ALS disease models

TDP-43 proteinopathies: pathological identification of brain regions differentiating clinical phenotypes

Molecular analysis and biochemical classification of TDP-43 proteinopathy

Distinct pathways leading to TDP-43-induced cellular dysfunctions

Neurotoxic effects of TDP-43 overexpression in C. elegans

An ALS-mutant TDP-43 neurotoxic peptide adopts an anti-parallel β-structure and induces TDP-43 redistribution

Splicing factors act as genetic modulators of TDP-43 production in a new autoregulatory TDP-43 Drosophila model

Oxr1 improves pathogenic cellular features of ALS-associated FUS and TDP-43 mutations

Atypical frontotemporal lobar degeneration with ubiquitin-positive, TDP-43-negative neuronal inclusions

TDP-43 pathology in familial frontotemporal dementia and motor neuron disease without Progranulin mutations

TDP-43 is deposited in the Guam parkinsonism–dementia complex brains

Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43

Corticospinal tract degeneration associated with TDP-43 type C pathology and semantic dementia

Loss of TDP-43 causes age-dependent progressive motor neuron degeneration

TDP-43 Phosphorylation by casein kinase Iε promotes oligomerization and enhances toxicity in vivo

TDP-43 causes differential pathology in neuronal versus glial cells in the mouse brain

Parkin-mediated reduction of nuclear and soluble TDP-43 reverses behavioral decline in symptomatic mice

 

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A highly conserved heterogeneous nuclear ribonucleoprotein (TAR DNA-binding protein-43, 43 kDa, 414 aa) that binds to the transcription-activating response region (see TAR). It is a major component of ubiquitin-positive, tau-negative inclusions in amyotrophic lateral sclerosis (ALS), and frontotemporal lobar degeneration (FTLD-U).

Subjects: Medicine and Health.


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