telomeric fusion site

'telomeric fusion site' can also refer to...


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A segment on human chromosome 2 that contains nucleotide sequences which once resided at or near telomeres. This region (2q13-2q14.1) is where two nonhomologous autosomes fused end-to-end to produce a single V-shaped chromosome. This telomere fusion occurred early in human evolution, and it explains why the human diploid chromosome number is 46, not 48—the value for chimpanzees, gorillas, and orangutans. See Chronology, 1991, Ijdo et al..

Subjects: Genetics and Genomics.

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