A widespread and abundant family of integral membrane proteins (tetraspanins) that have four transmembrane regions and both ends located in the cytoplasm. They interact with one another and with other membrane proteins to produce specific membrane microdomains in vesicles that shuttle between various membranous compartments. They can be subdivided into three distinct groups: physins, gyrins such as synaptogyrin, and secretory carrier-associated membrane proteins (SCAMPs). The tetraspanin web is the network of TVPs (tetraspanins) and their partner proteins (ADAMs and integrins) that facilitates cellular interactions and cell fusion.
Subjects: Medicine and Health.