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A glycoprotein (575 aa) of the luminal surface of endothelial cells that is a high-affinity receptor for thrombin. The thrombomodulin–thrombin complex activates protein C which degrades clotting factors V and VIII and acts as an anticoagulant. Mutations cause thrombophilia and a predisposition to myocardial infarction.

Subjects: Medicine and Health — Chemistry.

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