n. an inherited or acquired condition that predisposes individuals to thrombosis. Inherited thrombophilias are established causes of systemic thrombosis due to defects in proteins involved in regulating blood coagulation. Causes include Factor V Leiden gene mutation, a prothrombin gene mutation, deficiences in proteins C and S and antithrombin III, and hyperhomocysteinaemia (see homocysteine). —thrombophilicadj.
Subjects: Medicine and Health.