Overview

thrombospondin


'thrombospondin' can also refer to...

thrombospondins

thrombospondin

thrombospondin-related anonymous protein

thrombospondin-related anonymous protein

The Evolution of Thrombospondins and Their Ligand-Binding Activities

The thrombospondin 1–TGF‐β axis in fibrotic renal disease

Thrombospondin-1 in pulmonary arterial hypertension: what ails NOS?

Increased Cortical Expression of Two Synaptogenic Thrombospondins in Human Brain Evolution

Thrombospondin-1 Expression in Bladder Cancer: Association With p53 Alterations, Tumor Angiogenesis, and Tumor Progression

Activation of the Myc oncoprotein leads to increased turnover of thrombospondin-1 mRNA

Differential regulation of thrombospondin-1 and fibronectin by angiotensin II receptor subtypes in cultured endothelial cells

Thrombospondin-1 antagonizes nitric oxide-stimulated vascular smooth muscle cell responses

112 Thrombospondin-2 guards against aging-related cardiomyopathy by increasing beta 1-integrin mediated signaling

585 Mice lacking thrombospondin-4 developed exacerbated cardiac remodeling to pressure-overload

Thrombospondin 1—a regulator of adenoma growth and carcinoma progression in the APCMin/+ mouse model

Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation

DOP074. Thrombospondin 1 modulates monocyte properties to suppress intestinal mucosal inflammation

Thrombospondin orchestrates the tolerance-promoting properties of TGFβ-treated antigen-presenting cells

Enhanced expression of ephrins and thrombospondins in the dermis of patients with early diffuse systemic sclerosis: potential contribution to perturbed angiogenesis and fibrosis

 

More Like This

Show all results sharing these subjects:

  • Chemistry
  • Medicine and Health

GO

Show Summary Details

Quick Reference

A family of five distinct gene products, thrombospondins (TSP) 1–4 and cartilage oligomeric matrix protein, that are extracellular calcium-binding proteins involved in cell proliferation, adhesion, and migration. Thrombospondin I (TSP1, 1170 aa) is a homotrimeric glycoprotein (450 kDa) found in the α granules of platelets, and synthesized and secreted for incorporation into the extracellular matrix by a variety of cells including endothelial cells, fibroblasts, smooth muscle cells, and type II pneumocytes. It binds heparin, and various extracellular matrix components. TSP 2 (1172 aa) is similar in properties to TSP1. TSP 1 and 2 promote synaptogenesis in the central nervous system. TSP 3 (956 aa) is a developmentally regulated heparin binding protein. TSP 4 (961 aa) also has heparin-binding properties but differs in being a potential integrin ligand.

Subjects: Chemistry — Medicine and Health.


Reference entries

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.