thymidine phosphorylase

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A dimeric enzyme (EC, subunits 482 aa) that functions in the salvage pathway to catalyse the conversion of thymidine (and to a lesser extent, 2′-deoxyuridine) to produce thymine (or uracil) and 2′-deoxyribose-1-phosphate. It has also been isolated as platelet-derived endothelial cell growth factor (PD-ECGF), an angiogenic factor, and as gliostatin, an inhibitor of astrocyte and astrocytoma proliferation. Mutations are associated with mitochondrial neurogastrointestinal encephalomyopathy in which there are multiple deletions of mitochondrial DNA, possibly because of aberrant thymidine metabolism.

Subjects: Medicine and Health.

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