thymidine phosphorylase

'thymidine phosphorylase' can also refer to...

thymidine phosphorylase

thymidine phosphorylase

What Is the Role of Thymidine Phosphorylase in Tumor Angiogenesis?

Nucleoside Phosphonic Acids in Thymidine Phosphorylase Inhibition: Structure - Activity Relationship

Thymidine phosphorylase expression and benefit from capecitabine in patients with advanced breast cancer

High Levels of Thymidine Phosphorylase as an Independent Prognostic Factor in Renal Cell Carcinoma

Clinicopathologic and Prognostic Significance of an Angiogenic Factor, Thymidine Phosphorylase, in Human Colorectal Carcinoma

“Clinicopathologic and Prognostic Significance of an Angiogenic Factor, Thymidine Phosphorylase, in Human Colorectal Carcinoma”

Unbalanced deoxynucleotide pools cause mitochondrial DNA instability in thymidine phosphorylase-deficient mice

Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy

Thymidine phosphorylase expression is associated with time to progression in patients receiving low-dose, docetaxel-modulated capecitabine for metastatic breast cancer

Relationship of elevated tumour thymidine phosphorylase in node-positive breast carcinomas to the effects of adjuvant CMF

Correlation between Expression of Platelet-derived Endothelial Cell Growth Factor (Thymidine Phosphorylase) and Microvessel Density in Early-stage Human Colon Carcinomas

Pyrimidine Acyclic Nucleoside Phosphonates and Phosphorylated Analogs (Part 2): Syntheses and Investigation of Their Inhibitory Effects Towards Human Thymidine Phosphorylase

Preclinical Toxicity Evaluation of Erythrocyte-Encapsulated Thymidine Phosphorylase in BALB/c Mice and Beagle Dogs: An Enzyme-Replacement Therapy for Mitochondrial Neurogastrointestinal Encephalomyopathy


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A dimeric enzyme (EC, subunits 482 aa) that functions in the salvage pathway to catalyse the conversion of thymidine (and to a lesser extent, 2′-deoxyuridine) to produce thymine (or uracil) and 2′-deoxyribose-1-phosphate. It has also been isolated as platelet-derived endothelial cell growth factor (PD-ECGF), an angiogenic factor, and as gliostatin, an inhibitor of astrocyte and astrocytoma proliferation. Mutations are associated with mitochondrial neurogastrointestinal encephalomyopathy in which there are multiple deletions of mitochondrial DNA, possibly because of aberrant thymidine metabolism.

Subjects: Medicine and Health.

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