thymidylate synthase

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'thymidylate synthase' can also refer to...

thymidylate synthase

An update on thymidylate synthase inhibitors

Identification and characterization of thymidylate synthase from Neisseria gonorrhoeae

Construction of a homodimeric dihydrofolate reductase-thymidylate synthase bifunctional enzyme.

Translational repression of thymidylate synthase by targeting its mRNA

Identification of in Vivo Target RNA Sequences Bound by Thymidylate Synthase

An Evolutionary Analysis of Lateral Gene Transfer in Thymidylate Synthase Enzymes

Thymidylate Synthase Expression and Response to Neoadjuvant Chemotherapy in Patients With Advanced Head and Neck Cancer

Replacement set mutagenesis of the four phosphate-binding arginine residues of thymidylate synthase

Role of cysteine amino acid residues on the RNA binding activity of human thymidylate synthase

In vitro selection of an RNA sequence that interacts with high affinity with thymidylate synthase

Tolerance of 5-fluorodeoxyuridine resistant human thymidylate synthases to alterations in active site residues

Specific binding of Hoechst 33258 to site 1 thymidylate synthase mRNA

Efficient and seamless DNA recombineering using a thymidylate synthase A selection system in Escherichia coli

Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors

Case–control analysis of thymidylate synthase polymorphisms and risk of lung cancer

Association of the thymidylate synthase polymorphisms with esophageal squamous cell carcinoma and gastric cardiac adenocarcinoma

Sequence Analysis and Functional Study of Thymidylate Synthase from Zebrafish, Danio rerio

Prognostic Implications of the Expression of erbB2, Topoisomerase IIα and Thymidylate Synthase in Metastatic Gastric Cancer After Fluorouracil-based Therapy


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EC; systematic name: 5,10‐methylenetetrahydrofolate:dUMP C‐methyltransferase; an enzyme responsible for the formation of thymidylate, dTMP, by the de novo pathway. It catalyses reductive methylation of 2′‐deoxy‐5′‐uridylate, dUMP, by reaction with ...

Subjects: Chemistry.

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