Overview

TL1


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A TNF-like ligand (tumour necrosis factor ligand superfamily member 15, TNFSF15, vascular endothelial growth inhibitor; VEGI, 251 aa) that binds to death receptor DR3. TL1 is highly expressed in endothelial cells and may act as an angiogenesis inhibitor. Expression is up-regulated in Crohn's disease and polymorphisms in the TNFSF15 gene may be associated with susceptibility.

Subjects: Medicine and Health.


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