TNF receptors

'TNF receptors' can also refer to...

TNF receptors

TNF receptor-associated protein 2

Targeting TNF receptors in rheumatoid arthritis

TNF receptor‐associated protein 2

TNF receptor‐1‐associated death‐domain protein

Soluble Tumor Necrosis Factor (TNF) Receptors Conserve TNF Bioactivity in Meningitis Patient Spinal Fluid

Failure of anti-TNF therapy in TNF Receptor 1-Associated Periodic Syndrome (TRAPS)

Comment on: Failure of anti-TNF therapy in TNF Receptor 1-Associated Periodic Syndrome (TRAPS)

Comment on: Failure of anti-TNF therapy in TNF receptor 1-associated periodic syndrome (TRAPS)

TNF receptor II fusion protein with tandemly repeated Fc domains

Structural and biological features of the TNF receptor and TNF ligand superfamilies: Interactive signals in the pathobiology of Hodgkin's disease*

Neutralization of Tumor Necrosis Factor (TNF) by Antibody but not TNF Receptor Fusion Molecule Exacerbates Chronic Murine Tuberculosis

Tumor Necrosis Factor (TNF)—α—Induced Interleukin-8 in Human Blood Cultures Discriminates Neutralization by the p55 and p75 TNF Soluble Receptors

Defective Innate Antibacterial Host Responses during Murine Klebsiella pneumoniae Bacteremia: Tumor Necrosis Factor (TNF) Receptor 1 Deficiency versus Therapy with Anti–TNF-α

Plasma Patterns of Tumor Necrosis Factor-α (TNF) and TNF Soluble Receptors During Acute Meningococcal Infections and the Effect of Plasma Exchange

PS217. Persistent glucocorticoid receptor activation reduces M2-like microglia phenotypes via TNF- a pathway

010. A New Genetic Mutation in TNF Receptor-Associated Periodic Syndrome

Susceptibility to Burkholderia pseudomallei is associated with host immune responses involving tumor necrosis factor receptor-1 (TNFR1) and TNF receptor-2 (TNFR2)

Sarcoid-like granulomatosis in a patient treated by interleukin-1 receptor antagonist for TNF-receptor–associated periodic syndrome


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A superfamily (TNFRSF) of receptors that includes the receptors for tumour necrosis factor as well as Fas, CD40, CD27, and RANK. The type 1 receptor (CD120a, TNFRSF1A, p60, 455 aa) is present on most cell types and type 2 (CD120b, TNFRSF1B, p80, 461 aa) is mainly restricted to haematopoietic cells. Both bind TNFα and lymphotoxin (TNFβ) and have substantial sequence homology in the extracellular domain, but different signalling capacities. TNFRSF1A has a death domain and binding of TNF to the extracellular domain leads to homotrimerization and interaction with a number of cytoplasmic proteins (TRADD, TRAF, FADD). Mutations in the type 1 receptor are associated with periodic fever. The extracellular portion of the type 2 receptor can be produced by proteolysis and is used as a treatment for rheumatoid arthritis (TN Enbrel).

Subjects: Medicine and Health.

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