A superfamily (TNFRSF) of receptors that includes the receptors for tumour necrosis factor as well as Fas, CD40, CD27, and RANK. The type 1 receptor (CD120a, TNFRSF1A, p60, 455 aa) is present on most cell types and type 2 (CD120b, TNFRSF1B, p80, 461 aa) is mainly restricted to haematopoietic cells. Both bind TNFα and lymphotoxin (TNFβ) and have substantial sequence homology in the extracellular domain, but different signalling capacities. TNFRSF1A has a death domain and binding of TNF to the extracellular domain leads to homotrimerization and interaction with a number of cytoplasmic proteins (TRADD, TRAF, FADD). Mutations in the type 1 receptor are associated with periodic fever. The extracellular portion of the type 2 receptor can be produced by proteolysis and is used as a treatment for rheumatoid arthritis (TN Enbrel).
Subjects: Medicine and Health.