topoisomerase inhibitor

'topoisomerase inhibitor' can also refer to...

topoisomerase inhibitor

Topoisomerase inhibitors

Topoisomerase inhibitors

topoisomerase inhibitor

Topoisomerase I inhibitors: Review and update

In vitro antifungal activity of DNA topoisomerase inhibitors

Induction of endoreduplication by topoisomerase II catalytic inhibitors

In vitro effect of DNA topoisomerase inhibitors on Candida albicans

In-vitro activity of topoisomerase inhibitors against Pneumocystis carinii.

Topoisomerase II inhibitors, irrespective of their chemical composition, ameliorate experimental arthritis

Type II topoisomerases—inhibitors, repair mechanisms and mutations

Carcinogenicity of the Anticancer Topoisomerase Inhibitor, Amsacrine, in Wistar Rats

Convection-enhanced delivery of a topoisomerase I inhibitor (nanoliposomal topotecan) and a topoisomerase II inhibitor (pegylated liposomal doxorubicin) in intracranial brain tumor xenografts1

Rapid microtiter assays for poxvirus topoisomerase, mammalian type IB topoisomerase and HIV-1 integrase: application to inhibitor isolation

Emodin Triggers DNA Double-Strand Breaks by Stabilizing Topoisomerase II-DNA Cleavage Complexes and by Inhibiting ATP Hydrolysis of Topoisomerase II

3,4-Dimethoxyphenyl bis-benzimidazole, a novel DNA topoisomerase inhibitor that preferentially targets Escherichia coli topoisomerase I

Use of a topoisomerase I inhibitor (irinotecan, CPT-11) in metastatic adrenocortical carcinoma

The ras Oncogene-Mediated Sensitization of Human Cells to Topoisomerase II Inhibitor-Induced Apoptosis

Evaluation of anti-sleeping-sickness drugs and topoisomerase inhibitors in combination on Trypanosoma brucei


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Any one of a class of cytotoxic drugs that work by blocking the action of topoisomerase enzymes, which promote the uncoiling of the DNA double helix, a necessary preliminary to replication. Topoisomerase I inhibitors include irinotecan (Campto), administered by intravenous infusion for treating advanced colorectal cancer (especially in combination with fluorouracil); and topotecan (Hycamtin), given orally or by intravenous infusion for treating advanced ovarian cancer. Side-effects include delayed but severe diarrhoea and reduction in blood-cell production by the bone marrow. Topoisomerase II inhibitors include etoposide and doxorubicin.

Subjects: Medicine and Health.

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