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TP53


'TP53' can also refer to...

TP53

TP53

Germline TP53 Variants and Susceptibility to Osteosarcoma

Smoking, lung cancers and their TP53 mutations

The TP53 website: an integrative resource centre for the TP53 mutation database and TP53 mutant analysis

The TP53 signaling network in mammals and worms

Rare Variants in TP53 and Susceptibility to Neuroblastoma

Specific TP53 mutation pattern in radiation-induced sarcomas

New approach to gastric cancer classification based on TP53 mutation

Worse survival for TP53 (p53)-mutated breast cancer patients receiving adjuvant CMF

High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated Tp53-responsive luciferase reporter

High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated Tp53-responsive luciferase reporter

The role of TP53 and MDM2 polymorphisms in TP53 mutagenesis and risk of non-melanoma skin cancer

Methylation profile of TP53 regulatory pathway and mtDNA alterations in breast cancer patients lacking TP53 mutations

TP53 mutation spectrum in lung cancers and mutagenic signature of components of tobacco smoke: lessons from the IARC TP53 mutation database

CBIO-02. AMPLIFIED EGFR DRIVES TUMORIGENESIS IN TP53 WILD TYPE GLIOBLASTOMA THROUGH INHIBITION OF p53 FUNCTION BY DNA-PK/p53 BINDING

Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress

TP53 mutational status is predictive of pazopanib response in advanced sarcomas

TP53 mutations and codon 72 genotype—impact on survival among ovarian cancer patients

 

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The symbol for the tumor suppressor gene that encodes the p53 protein. TP53 contains 11 exons and is located at 17p13.1. Two promoters have been identified at the 5′ end of TP53. The first is 100–250 bp upstream of exon 1, and the second is in intron 1. The gene was first isolated in 1983 from mouse cells and subsequently from human, rat, rhesus monkey, cat, sheep, horse, rabbit, hamster, chicken, and Xenopus. Mutations of TP53 occur in about half of all human cancers. All of the small-cell lung carcinomas and the cancers found in patients with Li-Fraumeni syndrome (q.v.) have TP53 mutations. When introduced into cultured cells from human cancers, the TP53 genes suppress their proliferation. See Chronology, 1983, Oren and Levine; 1990, Baker et al.; anti-oncogenes.

Subjects: Genetics and Genomics.


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