transcriptional insulators

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The DNA elements that set boundaries on the actions of enhancer and silencer elements and so partition the eukaryotic genome into regulatory domains. The transcriptional repressor CTCF (CCCTC-binding factor) binds through multiple zinc fingers (of which it has eleven) to a range of unrelated DNA sequences and functions as a transcriptional insulator, repressor, or activator, depending on the context of the binding site.

Subjects: Medicine and Health.

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