The suppression of a mutant phenotype by introducing a specific wild-type nucleotide sequence into an embryo. A transposable element is generally used as a vector. The introduced wild-type gene sequences are said to “rescue” the mutant phenotype to normality. Transformation rescue is commonly used in germ line transformation experiments to identify functional components of a gene or to identify genomic sequences that correspond to a genetic locus. Also called plasmid rescue. See Chronology, 1982, Spradling and Rubin; P elements.
Subjects: Genetics and Genomics.