A large family of intercellular signaling molecules. These proteins are serine/threonine kinases, and they act by binding receptors on cell surfaces. The factors act as dimers, and their receptors are also dimers. TGF-βs play a role in embryonic development, cellular differentiation, hormone secretion, and immune suppression. See activin, cellular signal transduction, decapentaplegic.
Subjects: Genetics and Genomics.