An integral protein (q.v.) belonging to a large superfamily of transmembrane receptors that contain seven membrane-spanning domains. Most of the members of 7 TM receptors are G protein-coupled receptors (q.v.), each of which binds a signaling molecule on the extracellular side of the membrane and transduces a signal on the cytoplasmic side to initiate or inhibit biochemical reactions within the cell. Examples of 7 TM receptors are sensory and neurotransmitter receptors.
Subjects: Genetics and Genomics.