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A protein family (homologues of the Drosophila protein) that modulate protein kinase signalling pathways. Tribbles-1 (372 aa) inhibits AP-1 activation and interacts with several mitogen-activated protein kinases. Tribbles-2 is a regulator of the inflammatory activation of monocytes. Tribbles-3 (TRIB3) affects insulin signalling at the level of Akt-2.

Subjects: Chemistry — Medicine and Health.

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