tricyclic antidepressants

Show Summary Details

Quick Reference

A group of drugs that were used to treat moderate to severe depression. They have adrenergic and serotonergic effects and probably work by inhibiting the reuptake of norepinephrine and serotonin. They also decrease the effects of histamine on H1 receptors and have sedative effects. Have largely been replaced by selective serotonin reuptake inhibitors (SSRIs).

Subjects: Clinical Pharmacology and Therapeutics.

Reference entries

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.