Overview

triggering receptor expressed on myeloid cells 2


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(TREM-2)

One of a family of receptors that regulate myeloid cell function. TREM-2 is expressed on macrophages, microglia, and pre-osteoclasts and signals through the adaptor DAP12. Defects of TREM-2 and DAP12 result in a rare syndrome characterized by presenile dementia and bone cysts.

Subjects: Medicine and Health.


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