tumour promoter

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'tumour promoter' can also refer to...

tumour promoter

tumour promoters

Tumour-specific distribution of BRCA1 promoter region methylation supports a pathogenetic role in breast and ovarian cancer

Loss of WNK2 expression by promoter gene methylation occurs in adult gliomas and triggers Rac1-mediated tumour cell invasiveness

Tissue-specific imprinting of the ZAC/PLAGL1 tumour suppressor gene results from variable utilization of monoallelic and biallelic promoters

No association between the –308 polymorphism in the tumour necrosis factor α (TNFα) promoter region and polycystic ovaries

Overlapping DNA recognition motifs between Sp1 and a novel trans-acting factor within the wt1 tumour suppressor gene promoter

Array-based analysis of genomic DNA methylation patterns of the tumour suppressor gene p16INK4A promoter in colon carcinoma cell lines

Integrated analysis of chromosomal, microsatellite and epigenetic instability in colorectal cancer identifies specific associations between promoter methylation of pivotal tumour suppressor and DNA repair genes and specific chromosomal alterations

The −308 polymorphism in the tumour necrosis factor (TNF) gene promoter region and ex vivo lipopolysaccharide‐induced TNF expression and cytotoxic activity in Chilean patients with rheumatoid arthritis

A22The role of primary tumour sidedness, EGFR gene copy number and EGFR promoter methylation in RAS/BRAF wild type colorectal cancer patients receiving irinotecan/cetuximab

A Common Functional Polymorphism (C→A Substitution at Position −863) in the Promoter Region of the Tumour Necrosis Factor-α (TNF-α) Gene Associated With Reduced Circulating Levels of TNF-α


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Compounds that increase the probability of tumour formation when applied after administration of a primary carcinogen, although not themselves considered carcinogenic. The concept arose in experimental studies on rodents and the best-known agent was croton oil in which the active ingredients were phorbol esters (hence their curious misnomer as ‘tumour promoting activity’). They differ from cocarcinogens which are only active when administered concurrently with the primary carcinogen, although the distinction is rarely made. Most tumour promoters are probably carcinogens if tested more thoroughly, and may contribute to tumour progression.

Subjects: Medicine and Health.

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