Generally a gene (antioncogene, cancer susceptibility gene) encoding a negative regulator of the cell cycle, e.g. an inhibitor of a growth factor signalling system, that must be mutated or otherwise inactivated for unregulated proliferation (neoplasia). There are negative regulators of tumour suppressors (e.g. hdm2, mena) that, when overexpressed, increase suceptibility to tumours. The number of known and suspected tumour suppressors is growing: See BASC complex; bridging integrators; CTCF; death-associated protein; deleted in colorectal cancer; deleted in malignant brain tumours-1; exostosins; GCIP; H19 gene; ING1; INK4; IRFs; menin; merlin; myeloid derived suppressor cells; myopodin; p53; p107; parafibromin; PCGF; PINX1; PML body (PML protein); polyposis coli; prohibitins; PTEN; retinoblastoma (Rb); SMCT; tes; transmembrane proteins with EGF-like and 2 follistatin-like domains; tuberous sclerosis; von Hippel–Lindau tumour suppressor protein; Wilms' tumour; WWOX; zf9.
Subjects: Medicine and Health.