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A basic helix–loop–helix transcription factor that is involved in promoting the epithelial-mesenchymal transition. Twist-1 and -2 repress cytokine gene expression through interaction with RelA, and transiently inhibit Runx2 function during development of the skeleton. Loss-of-function mutations of the TWIST1 gene are responsible for Saethre–Chotzen syndrome.

Subjects: Chemistry — Medicine and Health.

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