two-pore channels

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Ion channels similar to voltage-sensitive calcium and sodium channels but that have only two of the domains, with six transmembrane segments not four. They are related to CATSPER and transient receptor potential channels. Two-pore channel 1 (TPC1, 816 aa) and TPC2 (752 aa) are voltage-sensitive calcium channels, and variations in TPC2 affect skin pigmentation.

Subjects: Medicine and Health.

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