ubiquitin C-terminal hydrolase L1

Show Summary Details

Quick Reference

A cysteine endopeptidase (UCH-L1, ubiquitin C-terminal esterase L1, EC, 212 aa) found in neurons (~2% of total protein) that is thought to cleave polyubiquitin (ubiquitin C) to monomers and hydrolyse bonds between ubiquitin and small adducts. Found in Lewy bodies, and mutations in UCH-L1 have been associated with type 5 Parkinson's disease; polymorphisms in the gene affect susceptibility to Parkinson's. A similar esterase UCH-L3 (230 aa) is found in a wider range of tissues.

Subjects: Medicine and Health.

Reference entries

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.