urocanic acid

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An intermediate formed in the degradation of L-histidine found as the trans isomer (t-UA) at ~30 mg/cm2 in the stratum corneum. Absorption of UV light will cause it to isomerize to the cis-isomer which may inhibit some immune responses, including contact and delayed hypersensitivity. Urocanic aciduria is an autosomal recessive metabolic disorder caused by a deficiency of the enzyme urocanase.

Subjects: Medicine and Health.

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