A multisubunit toxin (vacuolating cytotoxin) produced by type I Helicobacter pylori that causes large vacuoles in epithelial cells. There are six or seven identical subunits (1287 aa) which are proteolytically cleaved to produce 37- and 58-kDa fragments that behave as an AB toxin. The toxin binds to receptor-like protein tyrosine phosphatases on the surface of target cells. Antibodies to VacA are common even in asymptomatic individuals.
Subjects: Medicine and Health.