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'VacA' can also refer to...

Vac A


Lack of a relationship between Lewis antigen expression and cagA, CagA, vacA and VacA status of Irish Helicobacter pylori isolates

Helicobacter pylori vacA and cagA Genotypes in Mexican Adults and Children

Helicobacter pylori Vacuolating Cytotoxin, VacA, Is Responsible for Gastric Ulceration

Vacuolating Toxin Production in Clinical Isolates of Helicobacter pylori with Different vacA Genotypes

Community Perspectives Associated With the African PsA-TT (MenAfriVac) Vaccine Trials

Direct binding of gangliosides to Helicobacter pylori vacuolating cytotoxin (VacA) neutralizes its toxin activity

Reduced intracellular survival of Helicobacter pylori vacA mutants in comparison with their wild-types indicates the role of VacA in pathogenesis

Clinical relevance of the cagA, vacA and iceA genotypes of Helicobacter pylori in Brazilian clinical isolates

Infection with cagA- and vacA-positive and -negative strains of Helicobacter pylori in a mouse model

Comparison of serum antibody titers to Helicobacter pylori lipopolysaccharides, CagA, VacA and partially purified cellular extracts in a Japanese population

The diversity of vacA and cagA genes of Helicobacter pylori in East Asia

Combined serum IgG response to Helicobacter pylori VacA and CagA predicts gastric cancer

Prevalence of Helicobacter pylori pathogenicity-associated cagA and vacA genotypes among Pakistani dyspeptic patients

cagA gene and vacA alleles in Spanish Helicobacter pylori clinical isolates from patients of different ages

A Role for the Vacuolating Cytotoxin, VacA, in Colonization and Helicobacter pylori–Induced Metaplasia in the Stomach

Induced Helicobacter pylori vacuolating cytotoxin VacA expression after initial colonisation of human gastric epithelial cells

Helicobacter pylori VacA cytotoxin interacts with fibronectin and alters HeLa cell adhesion and cytoskeletal organization in vitro


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A multisubunit toxin (vacuolating cytotoxin) produced by type I Helicobacter pylori that causes large vacuoles in epithelial cells. There are six or seven identical subunits (1287 aa) which are proteolytically cleaved to produce 37- and 58-kDa fragments that behave as an AB toxin. The toxin binds to receptor-like protein tyrosine phosphatases on the surface of target cells. Antibodies to VacA are common even in asymptomatic individuals.

Subjects: Medicine and Health.

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