valosin-containing protein

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A structural protein (VCP, p97, 806 aa) of the AAA family that is complexed with clathrin and, like NSF, is involved in vesicle transport and fusion. Missense mutations in VCP are the cause of inclusion body myopathy with Paget's disease of bone and frontotemporal dementia (IBMPFD), probably by compromising ubiquitin-mediated protein quality control.

Subjects: Medicine and Health.

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