Overview

V(D)J recombination


'V(D)J recombination' can also refer to...

V(D)J recombination

V(D)J recombination

V(D)J recombination

V(D)J Recombination Defects

V(D)J recombination

Congenital defects in V(D)J recombination

Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination

The architecture of the 12RSS in V(D)J recombination signal and synaptic complexes

The RAG proteins in V(D)J recombination: more than just a nuclease

IMGT/GeneInfo: enhancing V(D)J recombination database accessibility

Increased frequency of aberrant V(D)J recombination products in core RAG-expressing mice

V(D)J recombination intermediates and non-standard products in XRCC4-deficient cells

DNA-PK is essential only for coding joint formation in V(D)J recombination

V(D)J recombination frequency is affected by the sequence interposed between a pair of recombination signals: sequence comparison reveals a putative recombinational enhancer element

Frequent and sex-biased deletion of SLX4IP by illegitimate V(D)J-mediated recombination in childhood acute lymphoblastic leukemia

Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice

The V(D)J recombination defect in the xrs-6 cell line results from a point mutation in the Ku80 gene

A new gene involved in DNA double-strand break repair and V(D)J recombination is located on human chromosome 10p

Regulation by phosphorylation of the zinc finger protein KRC that binds the κB motif and V(D)J recombination signal sequences

 

More Like This

Show all results sharing this subject:

  • Genetics and Genomics

GO

Show Summary Details

Quick Reference

The process by which most vertebrates assemble immunoglobin (Ig) and T cell receptor (TCR) genes during the development of lymphoid cells. In the germ cells, the genes that encode the variable portions of the Ig and T cell receptor heterodimers are split into V (variable), J (joining), and sometimes D (diversity) segments. In immature lymphoid cells, segments of each type are joined together to make a V-J or a V-D-J fusion product. V(D)J recombination involves DNA cleavage catalyzed by an element that behaves like a transposase (q.v.). The element is the product of two genes, RAG-1 and RAG-2 (q.v.). See Chronology, 1990, Oettinger et al.; allelic exclusion, B lymphocyte, immunoglobulin chains, immunoglobulin genes, somatic recombination, T cell receptor genes, T lymphocyte.

Subjects: Genetics and Genomics.


Reference entries

Users without a subscription are not able to see the full content. Please, subscribe or login to access all content.