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An RNA-binding protein (1289 aa) with multiple (14) KH domains found in the cytoplasm and the nucleus and implicated in heterochromatin formation, chromosome segregation and the localization of mRNAs to actively translating ribosomes. The conserved vigilin class of proteins have a high affinity for inosine-containing RNAs. High density lipoprotein-binding protein, also known as vigilin, seems to be the same protein but, oddly, is membrane associated and binds HDL molecules; it has been suggested that it may couple sterol metabolism to protein synthesis.

http://atvb.ahajournals.org/cgi/content/full/17/11/2350 Both roles for HBP/vigilin are discussed in an article in Arteriosclerosis, Thrombosis, and Vascular Biology (1997).

Subjects: Medicine and Health.

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