One of a group of antimitotic drugs (see also cytotoxic drug) derived from the periwinkle (Vinca rosea). Vinca alkaloids are used especially to treat leukaemias and lymphomas; they include vinblastine (Velbe), vincristine (Oncovin), and vindesine (Eldisine), which are administered intravenously. Vinorelbine (Navelbine), which can be administered intravenously or orally, is used in the treatment of advanced breast cancer and non-small-cell lung cancer. Vinca alkaloids are highly toxic; side-effects include myelosuppression, peripheral neuropathy, and severe irritation at the injection site.
Subjects: Medicine and Health.