A family of proteins (Wiskott–Aldrich syndrome proteins) involved in regulating actin polymerization that includes WASP (502 aa), N-WASP (WASP-like, WASL), WAVE1, 2, and 3 (WASP family, verprolin homology domain-containing proteins), WASP-interacting proteins (WIPF1 and 2). WASP has a GTP-binding site and links cdc42 and the actin cytoskeleton. Mutations in the gene encoding WASP are responsible for Wiskott–Aldrich syndrome. N-WASP is more broadly distributed than WASP itself which is mainly found in myeloid cells. See verprolins.
Subjects: Medicine and Health.