Wegener's granulomatosis

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An autoimmune disease predominantly affecting the nasal passages, lungs, and kidneys, characterized by the formation of necrotizing granuloma in addition to pulmonary vasculitis. It is associated with the presence of antineutrophil cytoplasmic antibodies (ANCA). Untreated, the disease is usually fatal, but it can be controlled (sometimes for years) with steroids, cyclophosphamide, and azathioprine. F. Wegener (1907–90), German pathologist

Subjects: Medicine and Health.

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