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A protein (WASP-interacting protein, WAS/WASL-interacting protein family member 1, WIPF, 1503 aa) that interacts with WASP. The adaptor protein CRKL binds directly to WIP and following T-cell receptor ligation, a CRKL–WIP–WASP complex is recruited by zap70 to lipid rafts and immunological synapses. A related protein (WASP-interacting protein-related protein, WIRE, WIPF2, 440 aa) interacts with WASP and profilin downstream of the platelet-derived growth factor receptor (PDGFR).

Subjects: Medicine and Health.

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