Overview

WNT protein


'WNT protein' can also refer to...

WNT protein

WNT protein

Lithium rescues toxicity of aggregate-prone proteins in Drosophila by perturbing Wnt pathway

Protein phosphatase 2A is required for mesalazine-dependent inhibition of Wnt/β-catenin pathway activity

Adiponectin stimulates Wnt inhibitory factor-1 expression through epigenetic regulations involving the transcription factor specificity protein 1

The EWS/FLI1 oncogenic protein inhibits expression of the Wnt inhibitor DICKKOPF-1 gene and antagonizes β-catenin/TCF-mediated transcription

Protein kinase C ζ is a positive modulator of canonical Wnt signaling pathway in tumoral colon cell lines

LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6

Antagonistic SR proteins regulate alternative splicing of tumor-related Rac1b downstream of the PI3-kinase and Wnt pathways

Protein N-glycosylation in oral cancer: Dysregulated cellular networks among DPAGT1, E-cadherin adhesion and canonical Wnt signaling

Secreted frizzled-related protein 2 (SFRP2) expression promotes lesion proliferation via canonical WNT signaling and indicates lesion borders in extraovarian endometriosis

Mutations in the C-terminus of the X protein of hepatitis B virus regulate Wnt-5a expression in hepatoma Huh7 cells: cDNA microarray and proteomic analyses

A novel human homologue of the Drosophila frizzled wnt receptor gene binds wingless protein and is in the Williams syndrome deletion at 7q11.23

Paracrine nitric oxide induces expression of cardiac sarcomeric proteins in adult progenitor cells through soluble guanylyl cyclase/cyclic-guanosine monophosphate and Wnt/β-catenin inhibition

 

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Any of a family of proteins that are involved in signal transduction pathways crucial in regulating cell proliferation, differentiation, and survival, both during embryological development and in later life. The components of the WNT signal pathway show marked similarity in a wide range of organisms, both invertebrates and vertebrates, signifying the pathway's fundamental role and ancient origin. The prototypical family member is encoded by the wingless gene (named after the effects of its mutation) in the fruit fly Drosophila. The Wingless protein (WG) plays a vital part in establishing the segmentation of the embryonic fly. It binds to the receptor protein Frizzled, which through the mediation of other pathway components, including the protein Dishevelled, causes the accumulation of β-catenin in the cytosol. This migrates to the nucleus, where it interacts with the transcription factor TCF (T-cell factor) to activate transcription of target genes. The homologous gene in mammals, Wnt1, acts through a similar pathway. WNT1 protein binds to receptors of the Frizzled family and is involved in development of the central nervous system. Other members of the WNT family have roles in the patterning of various tissues.

Subjects: Biological Sciences.


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