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wortmannin


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wortmannin

wortmannin

Wortmannin induces homotypic fusion of plant prevacuolar compartments

Wortmannin enhances the induction of micronuclei by low and high LET radiation

Wortmannin enhances the induction of micronuclei by low and high LET radiation

Wortmannin inhibits translation of tumor necrosis factor-α in superantigen-activated T cells

Augmentation of CTLA-4 expression by wortmannin: involvement of lysosomal sorting properties of CTLA-4

Wortmannin, a phosphatidylinositol 3-kinase inhibitor, blocks the assembly of peptide-MHC class II complexes.

Wortmannin and Li+ Specifically Inhibit Clathrin-Independent Endocytic Internalization of Bulk Fluid

An xrcc4 defect or Wortmannin stimulates homologous recombination specifically induced by double‐strand breaks in mammalian cells

Effects of wortmannin on insulin- and ischemia-induced stimulation of GLUT4 translocation and FDG uptake in perfused rat hearts

P154Wortmannin abolishes the protective effect of simvastatin against the ischaemia and reperfusion-induced ventricular arrhythmias in the anaesthetized canine

Wortmannin is a potent inhibitor of DNA double strand break but not single strand break repair in Chinese hamster ovary cells

Wortmannin-mediated inhibition of phosphatidylinositol 3-kinase activity triggers apoptosis in normal and neoplastic B lymphocytes which are in cell cycle

Inhibitory Effects of ML-9, Wortmannin, and Y-27632 on the Chemotaxis of Vascular Smooth Muscle Cells in Response to Platelet-Derived Growth Factor-BB

 

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A fungal metabolite, isolated from Penicillium wortmanni and other fungi, that is a fairly specific, covalent inhibitor of PI-3-kinases although it will inhibit some related kinases such as polo-like kinases, mTOR, and myosin light-chain kinase. It has a relatively short half-life in physiological solutions.

Subjects: Medicine and Health.


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