xanthine dehydrogenase

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A molybdenum-containing hydroxylase (XDH, EC, 1333 aa) involved in the oxidative metabolism of purines. It can be converted to xanthine oxidase (XO; EC by reversible sulphydryl oxidation or by irreversible proteolytic modification. XO-derived reactive oxygen species are thought to be mediators in the pathogenesis of cellular injury. Mutations in the XDH gene lead to xanthinuria type 1.

Subjects: Medicine and Health.

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