An oncogene originally identified in Yamaguchi avian sarcoma virus. The product (p62yes) is a src-family nonreceptor tyrosine kinase. There are multiple copies of yes-related genes in the human genome and YES1 may be translocated in follicular lymphoma. Yes-associated protein (YAP65) is a transcriptional coactivator that enhances p73-dependent apoptosis in response to DNA damage.
Subjects: Medicine and Health.