Overview

zap70


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A protein tyrosine kinase (ζ-chain-associated protein, 70 kDa, 619 aa) that associates with the ζ chain of the T-cell receptor and is tyrosine phosphorylated when the receptor binds ligand. Interacts with lck and fyn. Mutations in zap70 can cause a form of SCID.

Subjects: Chemistry — Medicine and Health.


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