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zf9


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zf9

 

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A zinc finger transcription factor (core promoter element-binding protein, COPEB, Krüppel-like factor 6, KLF6) from rat stellate cells (see Ito cells) that transactivates a key promoter driving stellate cell fibrogenesis. The human homologue, KLF6 (283, 290 aa), can be alternatively spliced to produce at least four isoforms and is a tumour suppressor mutated in some forms of prostate and gastric carcinoma. Wildtype KLF6 upregulates p21 (WAF1/CIP1) in a p53-independent manner and significantly reduces cell proliferation.

Subjects: Medicine and Health.


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